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Diet, supplements (e.g., niacin, NR), and exercise help, but may not suffice post-40 due to inefficiency and depletion.[18][19] Oral precursors like NMN increase NAD+ but bioavailability varies

What we can say with confidence is that the compounds target non-overlapping pathways, show no receptor competition in pharmacological models, and have individual safety profiles that don't predict catastrophic interaction